The effect of opioid receptor gene polymorphism (A118G) on postoperative tramadol consumption after gynecological surgery performed with a pfannenstiel incision

Introduction: The analgesic efficacy and side effects of opioid medications show great inter-individual differences. Genetic studies have indicated that this difference is considerably associated with the relationship between receptor. Therefore, in study it was aimed to investigate effect A118G polymorphism on postoperative tramadol consumption opioid-related side-effects after gynecological surgery performed. Material Methods: Evaluation made 80 patients I-II ASA status, scheduled for performed a pfannenstiel incision under general anesthesia. Genomic DNA extracted from blood samples. After surgery, all were equipped an intravenous Tramadol patient-controlled analgesia device measured. Pain scores measured numerical rating scale. All assessments prior gene analysis. In order detect genotype single point mutation, Polymerase Chain Reaction (PCR) Restriction Fragment Length Polymorphism(RFLP) methods used. Results: included included. Of these, 60(75%) detected homozygous 118AA(AA) 20(25%) heterozygous 118AG(AG). No 118GG(GG mutant) detected. Patients divided into 2 separate groups based their genotypes. total pain score group carrying AG allele significantly higher than AA allele. statistically significant respect side-effects. Conclusions: µ-opioid receptor has consumption.